The High-Grade Oxidative Profile (OXpr), Aortic Stiffness Parameters, and Hemogram-Derived Indices (HDI) as Predictors of Long-Term Major Adverse Cardiovascular Events (MACEs) Following Percutaneous Coronary Intervention (PCI) in Patients with Non-ST-Elev

Abstract

BACKGROUND.
Despite the achievements in the management of coronary heart disease (CHD), there is a need to appropriately tailor the long-term management strategies and risk stratification, particularly after percutaneous coronary intervention (PCI) because of a non-ST-elevation acute coronary syndrome (NSTE-ACS) or chronic coronary syndrome (CCS).
OBJECTIVES
The Present study aimed to (i) evaluate the long-term cardiovascular prognostic value of oxidative stress markers, arterial stiffness parameters, and hemogram-derived inflammatory indices and (ii) compare the long-term predictive performance of the abovementioned markers with the periprocedural SYNTAX score II (SS-II) in Georgian patients following PCI.
METHODS
After PCI because of NSTE-ACS or CCS, the annual incidence of 6-component MACEs, and values of the oxidative profile, arterial stiffness measurements, and hemogram-derived indices (HDI) were measured during the 36-month follow-up period in the development (100 patients with NSTE-ACS) and validation cohorts (91 patients with CCS), respectively.
RESULTS
By the multiple regression analysis NLR (0.505±0.069, p<0.0001), OXpr (0.181±0.076, p=0.018), SBPao (0.174±0.076, p=0.023), and PLR (0.164±0.056, p=0.004) are positively correlated with 36-month MACEs.
CONCLUSIONS
The oxidative stress profile, central systolic blood pressure, and hemogram-derived indices such as neutrophil-lymphocyte and monocytelymphocyte ratios may be novel independent predictors of long-term major adverse cardiovascular events.